AI in Safety and Efficacy of NSAIDs in OA

Abstract

Nonsteroidal anti-inflammatory drugs are commonly used to manage pain in osteoarthritis, but their use is associated with potential safety risks, particularly gastrointestinal and cardiovascular complications. This necessitates strategies to improve the safety and efficacy of NSAID use in OA patients. Artificial intelligence offers promising tools to address this challenge. This study explores the potential of AI to enhance the safety and efficacy of NSAIDs in OA by focusing on personalized medicine, optimized drug delivery, and real-time pain monitoring. We discuss how AI algorithms can be used to predict individual patient responses to NSAIDs, identify patients at high risk of adverse events, and tailor treatment strategies to minimize risks while maximizing therapeutic benefits. Furthermore, we examine the role of AI in developing novel drug delivery systems that can target NSAIDs directly to the affected joints, reducing systemic exposure and minimizing side effects.